Degama & SPAI Groups Ltd., Chief Science and Technology Officer at Degama Group Ltd. and SPAI Group Ltd., Atidim Technology Park, BLDG #4, 13th, Tel Aviv 61580, Israel; Department of Pharmaceutical Engineering, The Jerusalem College of Engineering, 26 Yaakov Shreibom St, Jerusalem 91035, Israel.
Department of Pharmaceutical Engineering, The Jerusalem College of Engineering, 26 Yaakov Shreibom St, Jerusalem 91035, Israel.
Carbohydr Polym. 2014 Feb 15;102:254-60. doi: 10.1016/j.carbpol.2013.11.042. Epub 2013 Dec 4.
The study aimed to investigate the swelling and degradation of calcium pectinate (CaP) films that were cross-linked by the innovative approach of adding aqueous calcium chloride (CaCl2) to pre-formed pectin films in situ. The films, cast from low methoxy pectin, were dried and cross-linked by immersion in a selected CaCl2 solution for a selected period. It was found that CaCl2 concentration, immersion time, and temperature affected the films' dissolution and swelling behaviors in simulated intestinal fluid. With lower CaCl2 concentration, more time was needed to form a proper film. Heat accelerated the cross-linking reaction, probably by elevating the cross-linked solution flux into the matrix. Depending upon cross-linking conditions, similar calcium contents in the CaP films resulted in different swelling and degradation behaviors. The degree of pectin esterification (DE) affected the films' degradation rate. The role of pectin molecular weight and DE on the films' mechanical properties was determined by stress/strain analysis.
本研究旨在探讨通过向预成型的果胶膜中添加水溶液氯化钙（CaCl2）的创新方法进行交联的钙果胶（CaP）膜的溶胀和降解。该膜由低甲氧基果胶制成，通过浸入选定的 CaCl2 溶液中干燥和交联一段时间。结果发现，CaCl2 浓度、浸泡时间和温度影响了膜在模拟肠液中的溶解和溶胀行为。较低的 CaCl2 浓度需要更长的时间才能形成合适的膜。热加速了交联反应，可能是通过提高交联溶液流入基质的通量来实现的。根据交联条件的不同，具有相似钙含量的 CaP 膜表现出不同的溶胀和降解行为。果胶酯化度（DE）影响膜的降解速率。通过应力/应变分析确定了果胶分子量和 DE 对膜机械性能的作用。
