七氟醚对大鼠肺缺血再灌注损伤组织通透性的影响
Effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury in rats.
作者信息
Li Xiao-Hui, Liu Zhong-Hua, Ma Hong-Bing, Li Yong, Zhao Hui, Che Jian-Bo, Liu Wei-Chao, Shi Gong-Ning
机构信息
Huaihe River Hospital, Henan University, Kaifeng 475000, Henan, China.
Medical School, Henan University, Kaifeng 475000, Henan, China.
出版信息
Asian Pac J Trop Med. 2014 Apr;7(4):276-9. doi: 10.1016/S1995-7645(14)60037-7.
OBJECTIVE
To investigate the effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury (LIRI) in rats.
METHODS
A total of 45 wistar rats were randomly divided into 3 groups I, II, III. Modified Eppinger method was adopted to establish the rat lung ischemia-reperfusion injury model. Group I served as the control group, group III as ischemia reperfusion group, group III as sevoflurane ischemia-reperfusion group. Blood gas index, lung permeability index (LPI) change, lung tissue pathology change and lung water content were observed and compared between groups of rats at different time points.
RESULTS
During ischemia reperfusion, all rats kept balance of the MAP during different time points, SPO2 of group II and III decreased significantly than I group (P<0.05); after reperfusion lung permeability index in Group II and III was higher than the control group significantly (P<0.05), 120 min after reperfusion LPI change and injury of group III was significantly lower than II group (P<0.05); interstitial and alveolar cavity effusion in of group III were lower than that of group II.
CONCLUSIONS
Sevoflurane pretreatment can reduce the lung tissue permeability, and LIRI plays a protective role in LIRI.
目的
探讨七氟醚对大鼠肺缺血再灌注损伤（LIRI）组织通透性的影响。
方法
将45只Wistar大鼠随机分为3组，即Ⅰ组、Ⅱ组、Ⅲ组。采用改良的埃平格法建立大鼠肺缺血再灌注损伤模型。Ⅰ组作为对照组，Ⅱ组为缺血再灌注组，Ⅲ组为七氟醚缺血再灌注组。观察并比较不同时间点各组大鼠的血气指标、肺通透性指数（LPI）变化、肺组织病理变化及肺含水量。
结果
缺血再灌注期间，各时间点所有大鼠MAP均保持平衡，Ⅱ组和Ⅲ组SPO2较Ⅰ组显著降低（P<0.05）；再灌注后Ⅱ组和Ⅲ组肺通透性指数显著高于对照组（P<0.05），再灌注120 min后Ⅲ组LPI变化及损伤程度显著低于Ⅱ组（P<0.05）；Ⅲ组间质及肺泡腔积液低于Ⅱ组。
结论
七氟醚预处理可降低肺组织通透性，对LIRI起到保护作用。
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