Lo Jean C Y, Darracq Michael A, Clark Richard F
Department of Toxicology, University of California, San Diego, San Diego, California.
J Emerg Med. 2014 May;46(5):670-9. doi: 10.1016/j.jemermed.2013.08.102. Epub 2014 Feb 6.
Historically, methylene blue (MB) has been used for multiple purposes, including as an antidote for toxin-induced and hereditary methemoglobinemia, ifosfamide-induced encephalopathy, and ackee fruit and cyanide poisoning; as an aniline dye derivative, antimalarial agent, and antidepressant.
Most recently, the use of MB has been advocated as a potential adjunct in the treatment of shock states. Our article reviews the role of MB in septic shock, anaphylactic shock, and toxin-induced shock. MB is proposed to increase blood pressure in these shock states by interfering with guanylate cyclase activity, and preventing cyclic guanosine monophosphate production and vasodilatation.
MB may be an adjunct in the treatment of septic shock, anaphylactic shock, and toxin-induced shock.
历史上，亚甲蓝（MB）有多种用途，包括作为毒素诱导和遗传性高铁血红蛋白血症、异环磷酰胺诱导的脑病以及西非荔枝果和氰化物中毒的解毒剂；作为苯胺染料衍生物、抗疟剂和抗抑郁药。
最近，有人主张将MB用作休克状态治疗的潜在辅助药物。我们的文章回顾了MB在感染性休克、过敏性休克和毒素诱导性休克中的作用。有人提出MB通过干扰鸟苷酸环化酶活性、阻止环磷酸鸟苷生成和血管舒张来提高这些休克状态下的血压。
MB可能是感染性休克、过敏性休克和毒素诱导性休克治疗的辅助药物。
