Kurz Max J, Wilson Tony W, Arpin David J
Department of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, United States; Center for Magnetoencephalography (MEG), University of Nebraska Medical Center, Omaha, NE, United States.
Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Department of Neurology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Center for Magnetoencephalography (MEG), University of Nebraska Medical Center, Omaha, NE, United States.
Brain Dev. 2014 Nov;36(10):870-7. doi: 10.1016/j.braindev.2014.01.003. Epub 2014 Feb 5.
The primary aim of this exploratory investigation was to determine if there are differences in cortical activation of children with spastic diplegic cerebral palsy (CP) and typically developing children during gait.
Functional near-infrared spectroscopy was used to measure the concentration of oxygenated hemoglobin that was present in the supplementary motor area, pre-central gyrus, post-central gyrus and superior parietal lobule as the children walked on a treadmill. A sagittal plane video was concurrently collected and later digitized to quantify the temporal gait variations.
(1) The children with CP had an increased amount of activation in the sensorimotor cortices and superior parietal lobule during gait, (2) the children with CP had a greater amount of variability or error in their stride time intervals, and (3) an increased amount of error in the temporal gait kinematics was associated with an increased amount of activity across the cortical network.
Our results suggest that the perinatal damage and subsequent neural reorganization that occurs with spastic diplegic CP may impact the functional cortical activity for controlling gait. Furthermore, our results imply the increased cortical activity of the somatosensory cortices and superior parietal cortices may underlie the greater amount of error in the temporal gait kinematics.
本探索性研究的主要目的是确定痉挛型双侧瘫脑瘫（CP）儿童与正常发育儿童在步态过程中皮质激活是否存在差异。
当儿童在跑步机上行走时，使用功能近红外光谱法测量辅助运动区、中央前回、中央后回和顶上小叶中氧合血红蛋白的浓度。同时收集矢状面视频，随后进行数字化处理以量化步态的时间变化。
（1）CP儿童在步态过程中感觉运动皮质和顶上小叶的激活量增加；（2）CP儿童的步幅时间间隔变异性或误差更大；（3）步态运动学时间误差的增加与整个皮质网络活动量的增加相关。
我们的结果表明，痉挛型双侧瘫CP所发生的围产期损伤及随后的神经重组可能会影响控制步态的功能性皮质活动。此外，我们的结果表明，体感皮质和顶上皮质的皮质活动增加可能是步态运动学时间误差增加的基础。
