Purves-Smith Fennigje M, Sgarioto Nicolas, Hepple Russell T
1Department of Kinesiology, 2McGill University Health Centre, and 3Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Exerc Sport Sci Rev. 2014 Apr;42(2):45-52. doi: 10.1249/JES.0000000000000012.
It is accepted widely that fast-twitch muscle fibers are preferentially impacted in aging muscle, yet we hypothesize that this is not valid when aging muscle atrophy becomes severe. In this review, we summarize the evidence of fiber type-specific effect in aging muscle and the potential confounding roles of fibers coexpressing multiple myosin heavy-chain isoforms and their histochemical identification.
人们普遍认为，快肌纤维在衰老肌肉中受到的影响更为显著，但我们推测，当衰老肌肉萎缩变得严重时，这种情况并不成立。在这篇综述中，我们总结了衰老肌肉中纤维类型特异性效应的证据，以及共表达多种肌球蛋白重链亚型的纤维的潜在混杂作用及其组织化学鉴定。
