Ladds Emma
Southmead Hospital, Bristol, UK.
BMJ Case Rep. 2014 Feb 7;2014:bcr2013202903. doi: 10.1136/bcr-2013-202903.
Four years after an orthoptic liver transplant for hepatocellular carcinoma secondary to alcoholic liver disease, the patient presented in a crescendo manner with skin infections and finally a septic right arm wound. The abscess was drained and cultures grew Mycobacterium tuberculosis. The patient reported a previous episode of 'pneumonia' and subsequent hospitalisations for recurrent chest infections, and following further investigation, he was diagnosed with disseminated tuberculosis. The infection responded to triple therapy, but primary closure of the arm wound was unsuccessful and it was treated conservatively with negative pressure wound therapy. The patient remains an inpatient 3 months after his presentation, responding well to therapy and anticipating imminent discharge. The patient's case serves as a reminder that infections are common in solid organ transplant recipients and clinicians should be aware of unusual or recurrent presentations in these patients, to allow for early diagnosis and timely management.
在因酒精性肝病继发肝细胞癌接受原位肝移植四年后,患者皮肤感染症状逐渐加重,最终右臂伤口发生脓毒症。脓肿引流后,培养物中生长出结核分枝杆菌。患者报告曾有一次“肺炎”发作,随后因反复胸部感染住院,进一步检查后,他被诊断为播散性结核病。感染对三联疗法有反应,但手臂伤口一期缝合未成功,采用负压伤口疗法进行保守治疗。患者就诊3个月后仍住院,对治疗反应良好,预计即将出院。该患者的病例提醒我们,实体器官移植受者中感染很常见,临床医生应意识到这些患者的异常或反复出现的症状,以便早期诊断和及时处理。