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[用异丙肌苷治疗亚急性硬化性全脑炎(SSPE)的结果评估]

[Evaluation of the results of treatment of SSPE (subacute sclerosing panencephalitis) with isoprinosine].

作者信息

Filipowicz A, Grudzińska B

机构信息

Kliniki Neurologii Sl. AM w Zabrzu.

出版信息

Neurol Neurochir Pol. 1987 Jul-Aug;21(4-5):352-6.

PMID:2451185
Abstract

The period of survival in the group of 36 boys and 18 girls with SSPE, as well as the condition of 13 living persons were examined. 30 children were treated with isoprinosine. A 3 years-long period of survival was significantly more frequent in the group of 18 children with long-term therapy by isoprinosine in comparison to 24 children without isoprinosine administration. The best results were observed in children with subacute course of the illness and many epileptic seizures. The 13 living persons are strongly damaged. One girl is decerebrated and 5 patients are completely helpless. The indications to isoprinosine therapy in SSPE are discussed.

摘要

对36名患有亚急性硬化性全脑炎(SSPE)的男孩和18名女孩的存活期以及13名在世者的状况进行了检查。30名儿童接受了异丙肌苷治疗。与24名未接受异丙肌苷治疗的儿童相比,在接受异丙肌苷长期治疗的18名儿童组中,3年生存期更为常见。在病情呈亚急性病程且癫痫发作频繁的儿童中观察到了最佳效果。13名在世者受到严重损伤。一名女孩脑死亡,5名患者完全无助。文中讨论了SSPE中异丙肌苷治疗的指征。

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