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利妥昔单抗-长春新碱化疗诱发急性前壁心肌梗死并心源性休克。

Rituximab-vincristine chemotherapy-induced acute anterior wall myocardial infarction with cardiogenic shock.

作者信息

Roy Ambuj, Khanna Naveen, Senguttuvan Nagendra Boopathy

机构信息

Department of Cardiology, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi 110029, India.

出版信息

Tex Heart Inst J. 2014 Feb;41(1):80-2. doi: 10.14503/THIJ-12-2853.

Abstract

We present a case of an elderly man with coronary artery disease who was diagnosed with non-Hodgkin lymphoma. Soon after the administration of chemotherapy, which included rituximab and vincristine, he developed acute myocardial infarction with cardiogenic shock. The condition was managed successfully with primary percutaneous coronary intervention. We briefly discuss the possible pathogenic mechanisms of chemotherapy-induced ischemic syndrome and the management of chemotherapy in patients with high cardiovascular risk.

摘要

我们报告一例患有冠状动脉疾病的老年男性,他被诊断为非霍奇金淋巴瘤。在给予包括利妥昔单抗和长春新碱的化疗后不久,他发生了急性心肌梗死并伴有心源性休克。通过初级经皮冠状动脉介入治疗成功控制了病情。我们简要讨论了化疗诱导的缺血综合征的可能致病机制以及心血管风险高的患者的化疗管理。

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