Ruzicka T, Ring J
Department of Dermatology, University of Munich, FRG.
Acta Derm Venereol. 1987;67(6):469-75.
The releasability of arachidonic acid-derived inflammatory mediators (eicosanoids) from peripheral blood leukocytes has been tested in patients with atopic eczema and healthy, non-atopic controls. Spontaneous and stimulated release of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and leukotriene C4 (LTC4) has been measured after challenge of cells with various concentrations of anti-IgE, Ca-ionophore A23187 and C5a. The maximal stimulation of cells with Ca-ionophore resulted in the generation of high amounts of all eicosanoids, which was essentially equal in both atopic and control groups. On the other hand, enhanced spontaneous and stimulated eicosanoid release was noted after immunological challenge using C5a and anti-IgE in the atopic eczema group. Thus, our data support the hypothesis of enhanced releasability of inflammatory mediators in atopic eczema.
已在特应性皮炎患者和健康非特应性对照者中测试了外周血白细胞中花生四烯酸衍生的炎症介质（类二十烷酸）的释放能力。在用不同浓度的抗IgE、钙离子载体A23187和C5a刺激细胞后，测量了前列腺素E2（PGE2）、白三烯B4（LTB4）和白三烯C4（LTC4）的自发释放和刺激释放。用钙离子载体对细胞进行最大刺激导致产生大量的所有类二十烷酸，这在特应性组和对照组中基本相同。另一方面，在特应性皮炎组中，使用C5a和抗IgE进行免疫刺激后，观察到类二十烷酸的自发释放和刺激释放增强。因此，我们的数据支持特应性皮炎中炎症介质释放能力增强的假说。
