Local and systemic effect of UVB irradiation in patients with chronic hand eczema.

The effect of local as well as whole body irradiation with UVB was investigated in patients with chronic hand eczema not responding to conventional topical treatment. UVB irradiation of the hands was significantly more effective than placebo. Whole body UVB irradiation combined with additional irradiation of the hands proved to be even more effective than local treatment in clearing chronic hand eczema. Due to the relatively fast relapse of the hand eczema after the UVB treatment period maintenance treatment is warranted. This could possibly be carried out by the patients at home, but under surveillance by a dermatologist.