Spencer K, Carpenter P
Biochemistry Department, Oldchurch Hospital, Romford, Essex, UK.
Ann Clin Biochem. 1988 Jan;25 ( Pt 1):85-8. doi: 10.1177/000456328802500112.
Normal values for neurone specific enolase in amniotic fluid have been found to follow a non gaussian distribution with a 1-99 centile range of 1.10-4.32 micrograms/L. Neurone specific enolase levels have been shown to be raised in the amniotic fluid of pregnancies complicated by anencephaly, although not those complicated by open spina bifida. Neurone specific enolase measured by radioimmunoassay is capable of totally discriminating between normal pregnancies and those complicated by anencephaly. The study demonstrates the possible value of investigating other neuronal proteins which may find value as adjuncts to amniotic fluid Alpha fetoprotein levels in the prenatal diagnosis of Neural Tube Defects.
已发现羊水神经元特异性烯醇化酶的正常数值呈非高斯分布，第1至99百分位数范围为1.10 - 4.32微克/升。研究表明，患有无脑儿的孕妇羊水中神经元特异性烯醇化酶水平会升高，而患有开放性脊柱裂的孕妇羊水该指标则不会升高。通过放射免疫测定法测量的神经元特异性烯醇化酶能够完全区分正常妊娠和患有无脑儿的妊娠。该研究表明，研究其他神经元蛋白可能具有一定价值，这些蛋白可能作为羊水甲胎蛋白水平的辅助指标，用于神经管缺陷的产前诊断。
