Zhang Qu, Jin Hong, Wang Lin, Xin BoBo, Zhang Jie, Zhou Yi, Sheng Sitong
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA,
Tumour Biol. 2014 Jun;35(6):5173-9. doi: 10.1007/s13277-014-1671-0. Epub 2014 Feb 11.
Inconsistent results are often found regarding the risk of genetic variants in lung cancer association studies. To alleviate these conflicts, we performed a large-scale meta-analysis to evaluate the effect of variants on lung cancer in East Asian population (Han Chinese, Japanese, and Korean). Forty-three genetic variants with data from at least three independent case-control studies were under investigation of which two variants (rs1800734 in hMLH1, rs2273953-rs1801173 bi-marker in P73) were first meta-analyzed in East Asians. We found that three variants in CYP1A1, GSTM1, and XRCC1 showed consistently significant associations with lung cancer in mixed analysis and stratified analysis, and several variants showed diverse effects interacting with different environmental factors in stratified analysis. Our study presents a comprehensive and systematic analysis of lung cancer association studies in East Asians and confirms the effect of three variants in lung cancer risk. Additionally, result from stratified analysis suggests the importance of inclusion of environmental factors, such as smoking and tumor histology, in the analysis.
在肺癌关联研究中，关于基因变异风险的结果常常不一致。为了缓解这些矛盾，我们进行了一项大规模的荟萃分析，以评估基因变异对东亚人群（汉族、日本人和韩国人）肺癌的影响。对43个有至少三项独立病例对照研究数据的基因变异进行了调查，其中两个变异（hMLH1中的rs1800734，P73中的rs2273953-rs1801173双标记）首次在东亚人群中进行荟萃分析。我们发现，在混合分析和分层分析中，CYP1A1、GSTM1和XRCC1中的三个变异与肺癌始终呈现出显著关联，并且在分层分析中，几个变异与不同环境因素相互作用呈现出不同影响。我们的研究对东亚人群的肺癌关联研究进行了全面系统的分析，并证实了三个变异对肺癌风险的影响。此外，分层分析结果表明在分析中纳入吸烟和肿瘤组织学等环境因素的重要性。
