Dagorn M, Poul M, Guillot P, Sanders P
Ministère de l'Agriculture, Laboratoire National des Médicaments Vétérinaires, Fougeres, France.
Food Addit Contam. 1988 Jan-Mar;5(1):51-8. doi: 10.1080/02652038809373662.
Ten 5-6 year-old unshorn ewes were dipped in a 0.025% lindane solution. Lindane residues in fat and plasma were analysed by gas liquid chromatography with an electron capture detector. The sensitivity of the method was 0.02 microgram/g for fat and 0.005 microgram/ml for plasma. Blood samples of 5 sheep were collected up to 84 days. The highest concentration of lindane detected in plasma was 107 +/- 37 ng/ml, 48 h after treatment. The disposition of lindane in plasma was studied by linear regression. Omental fat samples were removed by biopsies at 7 or 14 day intervals for 154 days. Fat concentrations of lindane were very high, respectively 30.46 +/- 14.6 ug/g, 8.09 +/- 4.57 micrograms/g, and 1.72 +/- 0.81 micrograms/g, 7, 28 and 70 days after dipping. In plasma and fat, the coefficients of elimination calculated by linear regression were similar (0.00190 +/- 0.00053 h-1 for plasma, 0.00196 +/- 0.00031 h-1 for fat). The tolerance recommended in France (2 micrograms/g in fat) was obtained 59.7 +/- 9.7 days after this treatment.
十只5至6岁未剪毛的母羊被浸入0.025%的林丹溶液中。采用带有电子捕获检测器的气液色谱法分析脂肪和血浆中的林丹残留量。该方法的灵敏度为脂肪0.02微克/克，血浆0.005微克/毫升。对5只绵羊的血样进行了长达84天的采集。处理后48小时，血浆中检测到的林丹最高浓度为107±37纳克/毫升。通过线性回归研究了林丹在血浆中的处置情况。在154天内，每隔7天或14天通过活检采集网膜脂肪样本。浸药后7天、28天和70天，脂肪中的林丹浓度非常高，分别为30.46±14.6微克/克、8.09±4.57微克/克和1.72±0.81微克/克。在血浆和脂肪中，通过线性回归计算出的消除系数相似（血浆为0.00190±0.00053小时-1，脂肪为0.00196±0.00031小时-1）。此次处理后59.7±9.7天达到了法国推荐的耐受量（脂肪中2微克/克）。
