Negi T, Toyoshima T, Murakami T H
Department of Physical Education, Kagawa Medical School, Japan.
Nihon Seirigaku Zasshi. 1987;49(11):674-81.
A series of experiments we examined in detail the effects of four chelating reagents, dithizone, DEDTC, oxine and EDTA, upon (1) Timm's staining in the hippocampal formation, (2) brain electrical activity recorded from hippocampal and cortical electrodes, (3) recovery effect with zinc acetate or zinc sulfate on abolished brain electrical activity, (4) open field activity, (5) toxicity, (6) and heart rate. Dithizone, DEDTC and oxine influenced all measures, and the degree of effect varied directory with dose. But EDTA has not any significant effect on biological system. Resulting data were summarized in Table 4.
我们进行了一系列实验，详细研究了四种螯合剂双硫腙、二乙氨基二硫代甲酸钠、8-羟基喹啉和乙二胺四乙酸对以下方面的影响：(1) 海马结构中的Timm染色；(2) 从海马和皮层电极记录的脑电活动；(3) 用醋酸锌或硫酸锌对消失的脑电活动的恢复作用；(4) 旷场活动；(5) 毒性；(6) 以及心率。双硫腙、二乙氨基二硫代甲酸钠和8-羟基喹啉影响了所有指标，且效应程度随剂量直接变化。但乙二胺四乙酸对生物系统没有任何显著影响。结果数据总结在表4中。
