Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, University of Pennsylvania , Department of Chemistry, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Org Lett. 2014 Mar 7;16(5):1446-9. doi: 10.1021/ol5002413. Epub 2014 Feb 12.
A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)2/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).
本文提出了一种新的合成方法，可用于制备二芳基甲基膦酸酯。该转化方法通过去质子交叉偶联过程（DCCP）实现了在苄基膦酸酯上引入芳基的功能。Pd(OAc)2/CataCXium A 催化剂可使苄基二异丙基膦酸酯衍生物与芳基溴化物发生反应，得到良好至优秀的分离收率（64-92%）。
