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血管内皮生长因子-B：一种更平衡的心脏新生血管形成方法？

VEGF-B: a more balanced approach toward cardiac neovascularization?

作者信息

Kupatt Christian, Hinkel Rabea

机构信息

Medizinische Klinik I Klinikum Großhadern, Munich, Germany.

出版信息

EMBO Mol Med. 2014 Mar;6(3):297-8. doi: 10.1002/emmm.201303730. Epub 2014 Feb 12.

DOI:10.1002/emmm.201303730
PMID:24521742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3958304/
Abstract

There is an urgent need for new pharmacologic approaches to combat the clinical consequences of ischemic cardiomyopathy. In this issue of EMBO Molecular Medicine, Kivelä et al show that transgenic expression of VEGF-B in the rat heart leads to expansion of the coronary arterial tree and an increase in functional coronary reserve, accompanied by a shift in myocardial metabolism from fatty acid to glucose utilization.

摘要

迫切需要新的药理学方法来对抗缺血性心肌病的临床后果。在本期《EMBO分子医学》中，基韦拉等人表明，在大鼠心脏中VEGF-B的转基因表达会导致冠状动脉树扩张和功能性冠状动脉储备增加，同时心肌代谢从脂肪酸利用转变为葡萄糖利用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/3958304/50fe6f9a4215/emmm0006-0297-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/3958304/50fe6f9a4215/emmm0006-0297-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/3958304/50fe6f9a4215/emmm0006-0297-f1.jpg

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1
VEGF-B: a more balanced approach toward cardiac neovascularization?血管内皮生长因子-B：一种更平衡的心脏新生血管形成方法？
EMBO Mol Med. 2014 Mar;6(3):297-8. doi: 10.1002/emmm.201303730. Epub 2014 Feb 12.
2
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.血管内皮生长因子B（VEGF-B）诱导的血管生长导致心脏代谢重编程和缺血耐受性。
EMBO Mol Med. 2014 Mar;6(3):307-21. doi: 10.1002/emmm.201303147. Epub 2014 Jan 21.
3
VEGF-B taken to our hearts: specific effect of VEGF-B in myocardial ischemia.VEGF-B走进我们的视野：VEGF-B在心肌缺血中的特定作用
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4
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.对血管内皮生长因子-B（VEGF-B）作用的重新评估表明，其在缺血心肌血管再生中的作用有限。
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Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.小鼠心脏中血管内皮生长因子-B的过表达会改变心脏脂质代谢并诱导心肌肥大。
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Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.血管内皮生长因子-B 作为一种冠状动脉生长因子在转基因大鼠中发挥作用，而不会引起血管生成、血管渗漏或炎症。
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VEGF-A and VEGF-B Coordinate the Arteriogenesis to Repair the Infarcted Heart with Vagus Nerve Stimulation.血管内皮生长因子A和血管内皮生长因子B通过迷走神经刺激协调动脉生成以修复梗死心脏。
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引用本文的文献

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Vascular endothelial growth factor-B: Impact on physiology and pathology.血管内皮生长因子-B：对生理和病理的影响。
Cell Adh Migr. 2018 May 4;12(3):215-227. doi: 10.1080/19336918.2017.1379634. Epub 2017 Nov 2.

本文引用的文献

1
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.血管内皮生长因子B（VEGF-B）诱导的血管生长导致心脏代谢重编程和缺血耐受性。
EMBO Mol Med. 2014 Mar;6(3):307-21. doi: 10.1002/emmm.201303147. Epub 2014 Jan 21.
2
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth.NO 不会触发 RGS4 降解以协调血管生成和心肌细胞生长。
J Clin Invest. 2013 Apr;123(4):1718-31. doi: 10.1172/JCI65112.
3
Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure.
经皮基因治疗增强心肌钙（CUPID）：晚期心力衰竭患者冠状动脉内肌浆网 Ca2+-ATP 酶基因治疗的 2 期试验。
Circulation. 2011 Jul 19;124(3):304-13. doi: 10.1161/CIRCULATIONAHA.111.022889. Epub 2011 Jun 27.
4
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.血管内皮生长因子-B 作为一种冠状动脉生长因子在转基因大鼠中发挥作用，而不会引起血管生成、血管渗漏或炎症。
Circulation. 2010 Oct 26;122(17):1725-33. doi: 10.1161/CIRCULATIONAHA.110.957332. Epub 2010 Oct 11.
5
Cotransfection of vascular endothelial growth factor-A and platelet-derived growth factor-B via recombinant adeno-associated virus resolves chronic ischemic malperfusion role of vessel maturation.通过重组腺相关病毒共转染血管内皮生长因子-A 和血小板衍生生长因子-B 可解决慢性缺血性灌注不良，促进血管成熟。
J Am Coll Cardiol. 2010 Jul 27;56(5):414-22. doi: 10.1016/j.jacc.2010.03.050.
6
Vascular endothelial growth factor B controls endothelial fatty acid uptake.血管内皮生长因子 B 控制内皮细胞脂肪酸摄取。
Nature. 2010 Apr 8;464(7290):917-21. doi: 10.1038/nature08945. Epub 2010 Mar 14.
7
Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms.血管内皮生长因子-B通过血管内皮生长因子受体-1和神经纤毛蛋白受体-1依赖性机制诱导心肌特异性血管生成和动脉生成。
Circulation. 2009 Feb 17;119(6):845-56. doi: 10.1161/CIRCULATIONAHA.108.816454. Epub 2009 Feb 2.
8
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.小鼠心脏中血管内皮生长因子-B的过表达会改变心脏脂质代谢并诱导心肌肥大。
Circ Res. 2008 Oct 24;103(9):1018-26. doi: 10.1161/CIRCRESAHA.108.178459. Epub 2008 Aug 28.
9
In vivo imaging shows abnormal function of vascular endothelial growth factor-induced vasculature.体内成像显示血管内皮生长因子诱导的脉管系统功能异常。
Hum Gene Ther. 2007 Jun;18(6):515-24. doi: 10.1089/hum.2006.162.
10
Current status of cardiovascular gene therapy.心血管基因治疗的现状
Mol Ther. 2007 Jul;15(7):1233-47. doi: 10.1038/sj.mt.6300175. Epub 2007 May 8.