消化系统中的腺苷酸环化酶。
Adenylyl cyclases in the digestive system.
作者信息
Sabbatini Maria Eugenia, Gorelick Fred, Glaser Shannon
机构信息
Department of Biological Sciences, Georgia Regents University, United States.
Department of Cell Biology and Medicine, Yale University, United States; VA CT, United States.
出版信息
Cell Signal. 2014 Jun;26(6):1173-81. doi: 10.1016/j.cellsig.2014.01.033. Epub 2014 Feb 9.
Abstract
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.
摘要
腺苷酸环化酶（ACs）是一类分布广泛的酶，其功能非常多样。已知有九种跨膜AC同工型可被Gαs激活。每种同工型在消化系统中都有其独特的表达模式，并受到Ca(2+)和其他细胞内信号的不同功能调节。除了跨膜同工型外，还有一种AC是可溶性的，且表现出独特的调节方式。在这篇综述中，我们将讨论ACs在消化系统中的基本结构、调节及其生理作用。
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