Carlson Russell M, Smith Nicholas C, Dux Katherine, Stuck Rodney M
ORA Orthopedics, Moline, Illinois, and Genesis Wound and Hyperbaric Medicine Institute, Davenport, Iowa (RMC).
Foot Ankle Spec. 2014 Apr;7(2):102-7. doi: 10.1177/1938640014522097. Epub 2014 Feb 11.
Human fibroblast-derived dermis skin substitute is a well-studied treatment for diabetic foot ulcers; however, no case series currently exist for its use in healing postoperative wounds of the lower extremity. A retrospective analysis was conducted on 32 lower extremity postoperative wounds treated weekly with human fibroblast-derived dermis skin substitute. Postoperative wounds were defined as a wound resulting from an open partial foot amputation, surgical wound dehiscence, or nonhealing surgical wound of the lower extremity. Wound surface area was calculated at 4 and 12 weeks or until wound closure if prior to 12 weeks. Postoperative wounds treated with weekly applications showed mean improvement in surface area reduction of 63.6% at 4 weeks and 96.1% at 12 weeks. More than 56% of all wounds healed prior to the 12-week endpoint. Additionally, only one adverse event was noted in this group. This retrospective review supports the use of human fibroblast-derived dermis skin substitute in the treatment of postoperative lower extremity wounds. This advanced wound care therapy aids in decreased total healing time and increased rate of healing for not only diabetic foot wounds but also postoperative wounds of the lower extremity, as demonstrated by this retrospective review.
人成纤维细胞来源的真皮皮肤替代物是一种经过充分研究的治疗糖尿病足溃疡的方法；然而，目前尚无关于其用于愈合下肢术后伤口的病例系列报道。对32例每周用人成纤维细胞来源的真皮皮肤替代物治疗的下肢术后伤口进行了回顾性分析。术后伤口定义为开放性部分足部截肢、手术伤口裂开或下肢手术伤口不愈合所致的伤口。在第4周和第12周计算伤口表面积，若在12周之前伤口闭合，则计算至伤口闭合时。每周进行治疗的术后伤口在第4周时表面积平均减少63.6%，在第12周时减少96.1%。超过56%的伤口在12周终点前愈合。此外，该组仅记录到1例不良事件。这项回顾性研究支持将人成纤维细胞来源的真皮皮肤替代物用于治疗下肢术后伤口。正如这项回顾性研究所表明的，这种先进的伤口护理疗法不仅有助于减少糖尿病足伤口的总愈合时间并提高愈合率，而且对下肢术后伤口也有同样效果。
