Zhang Qian, Hou Bo, Wang Lu, Wang Xiao-ying, Feng Feng, Jiang Bin, Shi Hong-xia, Ma Yi-gai, Liu Hui, Han Bing, Zhao Yong-qiang
Department of Hematology, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
Department of Radiology, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2013 Nov 26;93(44):3506-9.
To evaluate the significance of magnetic resonance imaging (MRI) T2(*) value analysis in patients with iron overload and compare it with other clinical parameters.
A total of 53 patients with suspected iron overload were recruited from four Beijing hospitals from December 2010 to December 2012. Their liver and heart T2(*) values were calculated and their serum ferritin (SF), transferrin saturation, blood transfusion volume and other clinical parameters were recorded and analyzed.
There were 37 males and 16 females with a medium age of 50 years(15-72 years). Their etiologies included myelodysplastic syndromes (MDS, n = 25), aplastic anemia (AA, n = 16), myelofibrosis (n = 5), hemochromatosis (n = 2) and β thalassaemia (n = 2), and 3 patients with high SF values were found on regular health examinations. Among them, there were transfusion history (n = 45), SF>1000 µg/L (n = 49), sign of iron overload (n = 10), abnormal liver function (n = 38) and hyperglycemia (n = 32). T2() value analysis showed that 10 patients had no evidence of iron overload, 43 patients had liver iron overload (14 mild, 22 moderate and 7 severe) and 2 patients had heart iron overload (1 MDS with heavy transfusion history and 1 AA with heart failure). No relations existed between T2() value and SF (P = 0.050) , T2() value and transfusion volume (P = 0.820) , and liver T2() value and heart T2(*) value (P = 0.129) .
MRI T2() value is an accurate way of quantitative detection of iron overload. It provides a comprehensive understanding of patients with iron overload in conjunctions with MRI T2() value and other clinical parameters.
评估磁共振成像（MRI）T2（*）值分析在铁过载患者中的意义，并将其与其他临床参数进行比较。
2010年12月至2012年12月期间，从北京四家医院招募了53例疑似铁过载患者。计算他们肝脏和心脏的T2（*）值，并记录和分析他们的血清铁蛋白（SF）、转铁蛋白饱和度、输血总量及其他临床参数。
53例患者中男性37例，女性16例，平均年龄50岁（15 - 72岁）。病因包括骨髓增生异常综合征（MDS，n = 25）、再生障碍性贫血（AA，n = 16）、骨髓纤维化（n = 5）、血色素沉着症（n = 2）和β地中海贫血（n = 2），另有3例患者在常规体检时发现SF值升高。其中，有输血史者45例，SF>1000 μg/L者49例，有铁过载体征者10例，肝功能异常者38例，血糖升高者32例。T2（）值分析显示，10例患者无铁过载证据，43例患者有肝脏铁过载（轻度14例，中度22例，重度7例），2例患者有心脏铁过载（1例有大量输血史的MDS患者和1例伴有心力衰竭的AA患者）。T2（）值与SF（P = 0.050）、T2（）值与输血总量（P = 0.820）、肝脏T2（）值与心脏T2（*）值之间均无相关性（P = 0.129）。
MRI T2（）值是定量检测铁过载的准确方法。结合MRI T2（）值及其他临床参数，可全面了解铁过载患者情况。
