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心脏手术中新型栓塞保护套管的体外研究结果。

A novel emboli protection cannula during cardiac surgery: in vitro results.

机构信息

Department of Cardiac Surgery, Rambam Health Care Campus, Haifa, Israel.

Department of Cardiac Surgery, Rambam Health Care Campus, Haifa, Israel.

出版信息

J Thorac Cardiovasc Surg. 2014 Aug;148(2):668-75. doi: 10.1016/j.jtcvs.2014.01.001. Epub 2014 Jan 12.

DOI:10.1016/j.jtcvs.2014.01.001
PMID:24521961
Abstract

OBJECTIVE

Intraoperative cerebral events are mainly caused by emboli generated by operative manipulation of the aorta. This study aimed to delineate the distribution profiles of emboli with 2 widely used cannulae and a third novel research cannula that simultaneously produces forward flow and backward suction to extract emboli from the distal aorta during cardiac surgery.

METHODS

The current in vitro study used a silicone model of the aortic arch and branches. The main outcome measure was the distribution profile of embolic particles of different sizes to the aortic branches; 2 commercial cannulae and a third novel cannula with and without suction were used. The research cannula was examined at different suction levels and the amount of particles retrieved was measured.

RESULTS

For the research curved-tip cannula, most of the small emboli were released into the brachiocephalic trunk in the model (P < .05). For the straight-tip cannula, most of the small emboli were released into the descending aorta (P < .05). Regarding the commercial curved-tipped cannula, most of the small emboli were released into the brachiocephalic trunk (47.14% ± 4.78%; P < .05) and the medium and large emboli were predominantly released into the descending aorta. Using suction, the research cannula retrieved most of the emboli released into the aorta for all particle sizes (50%-83%; P < .05).

CONCLUSIONS

A straight-tip cannula may be safer in terms of cerebral embolic consequences during cardiac surgery. Furthermore, the use of the research aortic cannula may be beneficial in the cardiac surgery setting by reducing the postoperative risk for stroke.

摘要

目的

术中脑事件主要由主动脉手术操作产生的栓子引起。本研究旨在描绘 2 种广泛使用的套管和 1 种新型研究套管在心脏手术中同时产生正向流和反向抽吸,从远端主动脉中提取栓子时的栓子分布情况。

方法

本体外研究使用主动脉弓和分支的硅酮模型。主要结局指标是不同大小的栓子颗粒到主动脉分支的分布情况;使用 2 种商业套管和 1 种具有和不具有抽吸功能的新型套管。检查了研究用弯曲尖端套管在不同抽吸水平下的情况,并测量了回收的颗粒数量。

结果

对于研究用弯曲尖端套管,在模型中,大部分小栓子释放到头臂干(P<.05)。对于直尖套管,大部分小栓子释放到降主动脉(P<.05)。对于商业弯曲尖端套管,大部分小栓子释放到头臂干(47.14%±4.78%;P<.05),中大和大栓子主要释放到降主动脉。使用抽吸时,研究用套管回收了所有粒径释放到主动脉的大部分栓子(50%-83%;P<.05)。

结论

在心脏手术期间,直尖套管在脑栓塞后果方面可能更安全。此外,在心脏手术中使用研究用主动脉套管可能通过降低术后中风风险而有益。

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