双相情感障碍和焦虑症。

Bipolar disorder and anxiety disorders.

作者信息

Latalova Klara, Prasko Jan, Grambal Ales, Havlikova Petra, Jelenova Daniela, Mainerova Barborá, Kamaradova Dana, Ociskova Marie, Sedlackova Zuzana, Sandoval Aneta

机构信息

Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.

Faculty of Philosophy, Department of Psychology, Palacky University Olomouc, Czech Republic.

出版信息

Neuro Endocrinol Lett. 2013;34(8):738-44.

PMID:24522015

Abstract

BACKGROUND

Anxiety disorders are common in patients with bipolar disorder and show considerable influence on the course of the disease and response to treatment.

METHOD

We conducted a series of literature searches using key words, such as bipolar disorder and anxiety disorders, as items in indexed fields. The studies were obtained through a MEDLINE search from 1970 to 2012. We also examined additional studies cited in articles from these searches or our previous studies.

RESULTS

Several studies have shown poorer outcomes for patients with bipolar and comorbid anxiety disorders. Some studies have indicated worse outcomes in patients with bipolar disorder and associated anxiety disorders. Shorter periods of euthymia, increased suicidal thoughts and an increased number of suicide attempts were observed. Whether the effective treatment of anxiety reduces suicide and the severity of bipolar disorder or improves the response to treatment remains unknown. There are no well-designed intervention studies in bipolar patients with anxiety symptoms.

CONCLUSION

Further studies concerning the influence of anxiety on the course of bipolar disorder would be useful.

摘要

背景

焦虑症在双相情感障碍患者中很常见，并且对疾病进程及治疗反应有相当大的影响。

方法

我们使用诸如双相情感障碍和焦虑症等关键词作为索引字段中的条目进行了一系列文献检索。这些研究通过1970年至2012年的MEDLINE搜索获得。我们还查阅了这些检索文章或我们之前研究中引用的其他研究。

结果

几项研究表明，双相情感障碍合并焦虑症的患者预后较差。一些研究表明，双相情感障碍伴发焦虑症的患者预后更差。观察到心境正常期较短、自杀观念增加以及自杀未遂次数增多。焦虑症的有效治疗是否能降低自杀率和双相情感障碍的严重程度或改善治疗反应尚不清楚。目前尚无针对有焦虑症状的双相情感障碍患者的精心设计的干预研究。