氨苄西林或氯霉素与莫西沙星治疗b型流感嗜血杆菌脑膜炎的前瞻性随机试验随访

Follow-up of prospective randomized trial of ampicillin or chloramphenicol versus moxalactam treatment of Haemophilus influenzae type b meningitis.

作者信息

Kaplan S L, Mason S K, Mason E O, Murphy M, Smith E O

机构信息

Myers-Black Infectious Disease Section, Meyer Center for Developmental Pediatrics, Houston, TX.

出版信息

J Pediatr. 1988 May;112(5):795-8. doi: 10.1016/s0022-3476(88)80707-8.

DOI:10.1016/s0022-3476(88)80707-8

PMID:2452245

Abstract

In a prospective randomized trial, moxalactam administered to 66 children was compared with ampicillin or chloramphenicol given to 68 children for the treatment of Haemophilus influenzae type b meningitis. Acute morbidity and mortality rates were equivalent between the two treatment groups. At 2 years after discharge, the results of psychologic tests (Bayley Scales of Infant Development or McCarthy Scales of Children's Abilities) were also equivalent between the two treatment groups for patients remaining in the study.

摘要

在一项前瞻性随机试验中，将给予66名儿童的羟羧氧酰胺菌素与给予68名儿童的氨苄青霉素或氯霉素用于治疗b型流感嗜血杆菌脑膜炎进行比较。两个治疗组的急性发病率和死亡率相当。出院2年后，对于仍在研究中的患者，两个治疗组的心理测试结果（贝利婴儿发育量表或麦卡锡儿童能力量表）也相当。