Reiling Erwin, Speksnijder Ewoud N, Pronk Amanda C M, van den Berg Sjoerd A A, Neggers Silvia J W, Rietbroek Ilma, van Steeg Harry, Dollé Martijn E T
National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Leiden University Medical Center, Department of Toxicogenetics, Leiden, The Netherlands.
Sci Rep. 2014 Feb 13;4:4091. doi: 10.1038/srep04091.
Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not support the previous findings in humans, suggesting that this polymorphism does not play a major role in development of glucose metabolism and body composition during ageing. Alternatively, the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.
TP53基因变异与癌症有关。密码子72处TP53多态性（rs1042522）的前等位基因与长寿有关。最近，我们发现同一等位基因可能参与衰老过程中葡萄糖代谢、身体成分和血压的维持。在此，我们评估了携带人类多态性的小鼠的葡萄糖耐量和身体成分。我们的数据不支持先前在人类中的发现，这表明该多态性在衰老过程中葡萄糖代谢和身体成分的发展中不起主要作用。或者，在测试的年龄范围内，小鼠模型可能不适用于验证这些与rs1042522相关的性状。
