Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
Macromol Rapid Commun. 2014 Apr;35(8):780-6. doi: 10.1002/marc.201300909. Epub 2014 Feb 13.
The synthesis of a novel photoreactive poly(ethylene glycol) (PEG)-based polymer with caged carbonyl groups is reported. We further demonstrate its use for the on-demand fabrication of hydrogels. For rapid gelation, a hydrazide-functionalized PEG is used as the second component for the hydrogel preparation. The photoreactive PEG-based polymer is designed for controlled cleavage of the protecting groups upon exposure to UV light releases free aldehyde moieties, which readily react with hydrazide groups in situ. This hydrogel system may find applications in controlled release drug delivery applications, when combined with in situ gelation. Furthermore, the possibility of forming gels specifically upon UV irradiation gives an opportunity for 3D fabrication of degradable scaffolds.
报道了一种新型光反应性聚乙二醇（PEG）基聚合物的合成，该聚合物带有笼状羰基基团。我们进一步证明了其用于按需制造水凝胶的用途。为了快速凝胶化，使用酰肼官能化的 PEG 作为水凝胶制备的第二组分。光反应性 PEG 基聚合物的设计目的是在暴露于紫外光下时控制保护基团的裂解，释放出游离的醛基，这些醛基可与原位的酰肼基团快速反应。当与原位凝胶化结合使用时，该水凝胶系统可能在控制释放药物输送应用中找到应用。此外，仅在紫外光照射下形成凝胶的可能性为可降解支架的 3D 制造提供了机会。
