Zabeau Lennart, Peelman Frank, Tavernier Jan
Biol Chem. 2014 May;395(5):499-514. doi: 10.1515/hsz-2013-0283.
The adipocyte-derived hormone/cytokine leptin acts as a metabolic switch, connecting the body's nutritional status to high energy consuming processes such as reproduction and immune responses. Inappropriate leptin responses can promote autoimmune diseases and tumorigenesis. In this review we discuss the current strategies to modulate leptin signaling and the possibilities for their use in research and therapy.
脂肪细胞衍生的激素/细胞因子瘦素作为一种代谢开关，将身体的营养状况与高能量消耗过程（如生殖和免疫反应）联系起来。不适当的瘦素反应会促进自身免疫性疾病和肿瘤发生。在这篇综述中，我们讨论了调节瘦素信号传导的当前策略及其在研究和治疗中的应用可能性。
