Hernandez L, Auerbach S, Hoebel B G
Department of Psychology, Princeton University, NJ 08544.
Life Sci. 1988;42(18):1713-23. doi: 10.1016/0024-3205(88)90037-9.
Phencyclidine (PCP; 20 micrograms in 0.5 microliter) was tested by local brain injection for neurochemical effects in the nucleus accumbens and striatum of rats. Changes in dopamine turnover could not be detected in postmortem tissue assays. In contrast, extracellular levels of dopamine significantly increased as measured by microdialysis in freely moving animals. PCP also increased extracellular levels of serotonin and decreased 3,4-dihydroxyphenylacetic acid (DOPAC), but did not change homovanillic acid (HVA) or 5-hydroxyindoleacetic acid (5HIAA). Microdialysis suggests that PCP acts in some dopamine terminal regions to increase extracellular dopamine and serotonin.
通过向大鼠伏隔核和纹状体局部脑内注射苯环己哌啶（PCP；0.5微升含20微克）来测试其神经化学效应。在死后组织检测中未检测到多巴胺周转率的变化。相比之下，在自由活动动物中通过微透析测量发现，多巴胺的细胞外水平显著升高。PCP还增加了血清素的细胞外水平，并降低了3,4 - 二羟基苯乙酸（DOPAC），但并未改变高香草酸（HVA）或5 - 羟基吲哚乙酸（5HIAA）。微透析表明，PCP在一些多巴胺终末区域起作用，以增加细胞外多巴胺和血清素水平。
