Fuxe K, von Euler G, Agnati L F, Ogren S O
Department of Histology, Karolinska Institute, Stockholm, Sweden.
Neurosci Lett. 1988 Feb 15;85(1):163-7. doi: 10.1016/0304-3940(88)90448-x.
The effects of galanin (10 nM) in vitro were analyzed on the binding characteristics of 5-hydroxytryptamine (5-HT) receptor subtypes in the ventral limbic cortex of the rat. It was found that galanin markedly decreased the Kd value of 5-HT1A binding, while there were no effects on the binding characteristics of the 5-HT1B or 5-HT2 radioligands. These results indicate that the existence of a selective intramembrane interaction between galanin receptors and 5-HT1A receptors in the rat ventral limbic cortex.
分析了甘丙肽（10纳摩尔）在体外对大鼠腹侧边缘皮质中5-羟色胺（5-HT）受体亚型结合特性的影响。发现甘丙肽显著降低了5-HT1A结合的解离常数（Kd）值，而对5-HT1B或5-HT2放射性配体的结合特性没有影响。这些结果表明在大鼠腹侧边缘皮质中甘丙肽受体与5-HT1A受体之间存在选择性的膜内相互作用。
