Cadet J L, Taylor E, Freed W J
Preclinical Neurosciences Section, NIMH, St. Elizabeth's Hospital, Washington, DC 20032.
Pharmacol Biochem Behav. 1988 Feb;29(2):381-5. doi: 10.1016/0091-3057(88)90172-4.
Chronic administration of IDPN leads to the development of a persistent syndrome which is characterized by lateral and vertical neck dyskinesias, random circling behaviors, and locomotor hyperactivity. Although the dihydropyridine (DHP) calcium channel antagonist nifedipine inhibited all aspects of the syndrome, lateral head dyskinesias (laterocollis) and circling abnormalities were the most significantly affected signs. Dysregulation of calcium-dependent processes might be involved in the pathogenesis of the IDPN-induced dyskinetic abnormalities and clinical disorders of movement in humans.
长期给予IDPN会导致一种持续性综合征的发展，其特征为颈部横向和纵向运动障碍、随机转圈行为以及运动亢进。尽管二氢吡啶（DHP）钙通道拮抗剂硝苯地平可抑制该综合征的所有方面，但头部横向运动障碍（斜颈）和转圈异常是受影响最显著的体征。钙依赖过程的失调可能参与了IDPN诱导的运动障碍异常及人类运动临床病症的发病机制。
