钙调蛋白拮抗剂对DNA损伤和细胞毒性的增强作用。
Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.
作者信息
Rosenthal S A, Hait W N
机构信息
Department of Medicine, Yale University School of Medicine, New Haven, CT 06510.
出版信息
Yale J Biol Med. 1988 Jan-Feb;61(1):39-49.
Abstract
Many physical and chemical agents used in anti-neoplastic therapy are known to act by effecting DNA damage. The possibility that calmodulin may be an important modulator of the response to DNA damage in eukaryotic cells has been explored in a number of studies which use calmodulin antagonists in combination with agents known to damage DNA. We review these studies and discuss the therapeutic potential of calmodulin antagonists in combination therapy.
摘要
已知许多用于抗肿瘤治疗的物理和化学药物通过造成DNA损伤来发挥作用。在一些研究中，人们探索了钙调蛋白可能是真核细胞中对DNA损伤反应的重要调节因子这一可能性，这些研究将钙调蛋白拮抗剂与已知会损伤DNA的药物联合使用。我们回顾了这些研究，并讨论了钙调蛋白拮抗剂在联合治疗中的治疗潜力。
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本文引用的文献
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Calmodulin stimulates DNA synthesis by rat liver cells.钙调蛋白刺激大鼠肝细胞的DNA合成。
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Single-agent chemotherapy of a solid murine tumor assayed by growth delay and cell survival.通过生长延迟和细胞存活检测对实体小鼠肿瘤进行单药化疗。
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Changes in calmodulin and its mRNA accompany reentry of quiescent (G0) cells into the cell cycle.钙调蛋白及其信使核糖核酸的变化伴随着静止（G0）细胞重新进入细胞周期。
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Correlation between potency of calmodulin inhibitors and effects on cellular levels and cytotoxic activity of doxorubicin (adriamycin) in resistant P388 mouse leukemia cells.钙调蛋白抑制剂的效力与对耐药P388小鼠白血病细胞中阿霉素（ Adriamycin）的细胞水平及细胞毒性活性影响之间的相关性
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Potentiation of radiation response of a mouse fibrosarcoma by phenothiazine drugs.吩噻嗪类药物对小鼠纤维肉瘤辐射反应的增强作用。
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Chlorpromazine: a potential anticancer agent?氯丙嗪：一种潜在的抗癌药物？
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