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对瓷化主动脉进行交叉钳夹:一种针对高危患者的替代技术。

Cross-clamping a porcelain aorta: an alternative technique for high-risk patients.

作者信息

Hartert Marc, Conzelmann Lars O, Mehlhorn Uwe, Schnelle Nalan, Werner Christian, Vahl Christian-Friedrich

机构信息

Department of Cardiothoracic and Vascular Surgery, University Medical Center, Johannes Gutenberg University, Mainz, Germany -

Department of Cardiothoracic and Vascular Surgery, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

出版信息

J Cardiovasc Surg (Torino). 2018 Oct;59(5):737-745. doi: 10.23736/S0021-9509.16.07834-X. Epub 2014 Feb 13.

DOI:10.23736/S0021-9509.16.07834-X
PMID:24525522
Abstract

BACKGROUND

Aortic cross-clamping in patients with porcelain aorta is associated with high mortality and morbidity rates. The aim is to establish a new approach to improve the outcome in this high-risk population.

METHODS

Between September 2007 and November 2012, 42 patients with an aortic (N.=33; 81.3±6.4 years) or mitral valve disease (N.=9; 80.3±5.7) combined with a porcelain aorta underwent aortic (AVR) or mitral valve replacement (MVR). After arterial cannulation via distal aortic arch or femoral artery, longitudinal aortotomy under total cardiopulmonary bypass (CPB) was performed. The aorta was slowly clamped, thus mobilized atherosclerotic material could leave the aorta through the open incision. Subsequent to the actual operation, the aorta was gradually unclamped. Again, plaques were flushed out via the still open aortotomy ("open proximal ascending aorta").

RESULTS

Intraoperatively, no technical no problems occurred. Mean CPB time was 92.2±27.9 min (AVR) and 92.3±36.3 min (MVR); cardiac ischemia time was 74.3±26.7 min (AVR) and 77.1±31.6 min (MVR). Surgical revision was necessary in three patients (7.1%) due to major bleedings. Two AVR-patients suffered from minor stroke and one MVR-patient from major stroke (neurological deficit rate =7.1%). Transient ischemic attacks occurred in three patients (7.1%), another three patients (7.1%) required temporary hemofiltration. Neither gastrointestinal disorders nor respiratory failure or valve-related problems were noted. 30-day mortality was 6.9%.

CONCLUSIONS

Cross-clamping with "open proximal ascending aorta" is effective and the incidence of stroke and systemic embolization in patients with porcelain aorta is low compared to literature.

摘要

背景

瓷化主动脉患者进行主动脉交叉钳夹术与高死亡率和高发病率相关。目的是建立一种新方法以改善这一高危人群的治疗结果。

方法

2007年9月至2012年11月期间,42例患有主动脉疾病(n = 33;81.3±6.4岁)或二尖瓣疾病(n = 9;80.3±5.7岁)合并瓷化主动脉的患者接受了主动脉瓣置换术(AVR)或二尖瓣置换术(MVR)。经远端主动脉弓或股动脉进行动脉插管后,在全心肺转流(CPB)下进行纵行主动脉切开术。缓慢钳夹主动脉,这样被松动的动脉粥样硬化物质可通过开放切口离开主动脉。实际手术之后,逐渐松开主动脉钳夹。再次通过仍开放的主动脉切口(“开放的升主动脉近端”)将斑块冲洗出来。

结果

术中未出现技术问题。平均CPB时间为92.2±27.9分钟(AVR)和92.3±36.3分钟(MVR);心脏缺血时间为74.3±26.7分钟(AVR)和77.1±31.6分钟(MVR)。3例患者(7.1%)因大出血需要进行手术修正。2例AVR患者发生轻度卒中,1例MVR患者发生重度卒中(神经功能缺损率 = 7.1%)。3例患者(7.1%)发生短暂性脑缺血发作,另外3例患者(7.1%)需要进行临时血液滤过。未发现胃肠道疾病、呼吸衰竭或瓣膜相关问题。30天死亡率为6.9%。

结论

“开放的升主动脉近端”交叉钳夹术是有效的,与文献报道相比,瓷化主动脉患者的卒中和全身性栓塞发生率较低。

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