Malomvölgyi B, Hadházy P, Magyar K
Department of Pharmacodynamics, Semmelweis University, Medical School, Budapest, Hungary.
Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:113-21.
The role of endothelium on the responses of the perfused rabbit renal artery segments to vasoconstrictor and vasodilator agents was studied. The vasoconstrictor responses of rabbit renal arteries to phenylephrine were enhanced by endothelium destruction. Acetylcholine (ACh), calcium-ionophore (A23187) and substance P (SP), in the presence of indomethacin, induced endothelium-dependent vasodilation of the phenylephrine-constricted renal arteries. Nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, significantly reduced the dilator responses to ACh, A23187 and SP, but did not reduce the responses to sodium nitrite. In conclusion, our results provide evidence for the involvement of lipoxygenase products in the endothelium-dependent vasodilation of rabbit renal arteries to ACh, A23184 and SP.
研究了内皮对灌注兔肾动脉段对血管收缩剂和血管舒张剂反应的作用。破坏内皮可增强兔肾动脉对去氧肾上腺素的血管收缩反应。在消炎痛存在的情况下，乙酰胆碱（ACh）、钙离子载体（A23187）和P物质（SP）可诱导去氧肾上腺素收缩的肾动脉出现内皮依赖性血管舒张。脂氧合酶抑制剂去甲二氢愈创木酸（NDGA）显著降低了对ACh、A23187和SP的舒张反应，但未降低对亚硝酸钠的反应。总之，我们的结果为脂氧合酶产物参与兔肾动脉对ACh、A23184和SP的内皮依赖性血管舒张提供了证据。
