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十二指肠腺瘤内镜切除术后的急性并发症

[Acute complications after endoscopic resection of duodenal adenomas].

作者信息

König J, Kaiser A, Opfermann P, Manner H, Pohl J, Ell C, May A D

出版信息

Z Gastroenterol. 2014 Feb;52(2):187-92. doi: 10.1055/s-0033-1350121. Epub 2014 Feb 13.

Abstract

With the increasing technological development of endoscopy in recent years the diagnosis of and endoscopic therapy for duodenal adenomas has gained in importance. Due to its potentially malignant transformation an effective and safe therapy is necessary. The endoscopic resection has been shown to be safe and effective, even in cases of resection of large duodenal adenomas. Several studies have supported this thesis but are based on relatively small numbers of patients. In our clinic we have performed endoscopic resections of 178 duodenal adenomas over a period of 14 years, including sporadic duodenal adenomas as well as adenomas in familial polyposis syndromes. The aim of this retrospective analysis was to determine the acute complications associated with this technique. The rate of severe complications such as major bleeding or perforations was 9%. Further complications were minor bleeding (15.7%), pain needing treatment with analgesia (6.7%), fever (2.8%) and pancreatitis (0.6%). Summing up our experience with the endoscopic resection of adenomas of the small bowel we also consider the endoscopic resection of duodenal adenomas in most cases as a safe and effective alternative to surgical therapy. Because of the potential complications and their management especially in the resection of large adenomas with a size more than 2 cm, the endoscopic resection should be performed on an inpatient basis in experienced centres.

摘要

近年来,随着内镜技术的不断发展,十二指肠腺瘤的诊断及内镜治疗变得越发重要。由于其具有潜在的恶变可能,因此需要一种有效且安全的治疗方法。内镜下切除已被证明是安全有效的,即使是在切除较大的十二指肠腺瘤时也是如此。多项研究支持了这一观点,但这些研究的患者数量相对较少。在我们诊所,我们在14年的时间里对178例十二指肠腺瘤进行了内镜下切除,包括散发性十二指肠腺瘤以及家族性息肉病综合征中的腺瘤。这项回顾性分析的目的是确定与该技术相关的急性并发症。严重并发症如大出血或穿孔的发生率为9%。其他并发症包括轻微出血(15.7%)、需要使用镇痛药治疗的疼痛(6.7%)、发热(2.8%)和胰腺炎(0.6%)。总结我们对小肠腺瘤内镜下切除的经验,我们也认为在大多数情况下,十二指肠腺瘤的内镜下切除是手术治疗的一种安全有效的替代方法。由于存在潜在并发症及其处理,特别是在切除直径超过2 cm的大腺瘤时,内镜下切除应在有经验的中心住院进行。

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