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巨大的骶骨骨巨细胞瘤:一例报告。

Huge giant cell tumor of the sacrum: A case report.

作者信息

Qin Li-Feng, Peng Dan, Qin Li-Hua, Xu Min, Fang Han, Zhang Qing

机构信息

Department of Orthopedics, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410010, P.R. China.

Department of Gynecology, Nursing School of Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.

出版信息

Oncol Lett. 2014 Mar;7(3):894-896. doi: 10.3892/ol.2014.1812. Epub 2014 Jan 17.

DOI:10.3892/ol.2014.1812
PMID:24527097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3919884/
Abstract

The current report describes the case of a 29-year-old female with a sacral giant cell tumor (GCT) during pregnancy. Originally, the patient presented with severe pain in the lumbosacral region, radiating posterolaterally from the lumbar spine into the bilateral thigh and subsequently, into the bilateral crus posterolaterally. Plain X-rays, computed tomography and magnetic resonance imaging showed osteolytic destruction of the sacrococcygeal bones and a huge soft-tissue mass with features of a chordoma. The patient underwent a partial en bloc sacrectomy (partial S1 and completely below) and curettage for tumors located at the sacroiliac joint and underlying left ilium, with bilateral internal iliac arteries ligated to control intraoperative hemorrhage. The patient's bilateral S2 nerve roots were killed. The diagnosis of conventional GCT was determined based on the histopathological examination of the resected specimen. Urinary and bowel functions were recovered by exercising.

摘要

本报告描述了一名29岁妊娠期骶骨巨细胞瘤(GCT)女性患者的病例。最初,患者表现为腰骶部剧痛,从腰椎向双侧大腿后外侧放射,随后又向双侧小腿后外侧放射。X线平片、计算机断层扫描和磁共振成像显示骶尾骨骨质溶解破坏,并有一个具有脊索瘤特征的巨大软组织肿块。患者接受了部分整块骶骨切除术(部分S1及以下完全切除),并对位于骶髂关节和左髂骨下方的肿瘤进行刮除术,同时结扎双侧髂内动脉以控制术中出血。患者双侧S2神经根被切断。根据切除标本的组织病理学检查确定为传统型GCT。通过锻炼,患者的排尿和排便功能得以恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7404/3919884/545f1efb3296/OL-07-03-0894-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7404/3919884/24fa92574436/OL-07-03-0894-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7404/3919884/01528cf3d8ae/OL-07-03-0894-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7404/3919884/545f1efb3296/OL-07-03-0894-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7404/3919884/24fa92574436/OL-07-03-0894-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7404/3919884/01528cf3d8ae/OL-07-03-0894-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7404/3919884/545f1efb3296/OL-07-03-0894-g02.jpg

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本文引用的文献

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PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone.甲状旁腺激素相关蛋白通过骨巨细胞瘤基质细胞增加 RANKL 的表达。
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Regression of giant cell tumor of the cervical spine with bisphosphonate as single therapy.二膦酸盐单药治疗颈椎巨细胞瘤的消退。
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Bone and soft tissue tumors of hip and pelvis.髋和骨盆的骨和软组织肿瘤。
唑来膦酸负载骨水泥作为骶骨骨巨细胞瘤刮除术后的局部辅助治疗。
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Surgical excision of sacral tumors assisted by occluding the abdominal aorta with a balloon dilation catheter: a report of 3 cases.球囊扩张导管阻断腹主动脉辅助下骶骨肿瘤手术切除:附3例报告
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