Unit of Spinal Surgery, University Hospital of Bordeaux, Bordeaux, France.
Spine (Phila Pa 1976). 2012 Mar 15;37(6):E396-9. doi: 10.1097/BRS.0b013e31823ed70d.
A case report.
To describe a case of regression of a giant cell tumor (GCT) of the cervical spine, which was treated with zoledronic acid as single therapy.
Bisphosphonates are antiresorptive drugs used in patients with myeloma and bone metastases to treat pain and skeletal events. Despite the emerging evidence of antitumoral effects in adjuvant therapy for GCT of bone, the use of bisphosphonates as a single agent has not been described.
Case study with follow-up examination and radiological control 36 months after the beginning of therapy. A review of the literature is also provided.
The imaging data at admission evidenced an extensive osteolytic lesion on C5 and C6 vertebral bodies. An open biopsy confirmed the diagnosis of GCT. It was decided to immobilize the cervical spine with rigid collar and to start monthly intravenous zoledronic acid. The subsequent clinical and radiological follow-up during 3 years revealed a marked regression of the lesion.
The use of a bisphosphonate agent for GCT of the cervical spine showed potential therapeutic benefits as previously described for other osteolytic disorders. This finding could lead to further investigation on the role and true value of these drugs as possible adjuvants in the management of GCT of bone.
病例报告。
描述一例颈椎巨细胞瘤（GCT）经唑来膦酸单药治疗后消退的病例。
双膦酸盐是一种抗吸收药物，用于治疗骨髓瘤和骨转移患者的疼痛和骨骼事件。尽管有证据表明双膦酸盐在骨 GCT 的辅助治疗中有抗肿瘤作用，但尚未描述将其作为单一药物使用。
治疗开始后 36 个月进行随访检查和影像学对照的病例研究。同时提供文献复习。
入院时的影像学数据显示 C5 和 C6 椎体广泛溶骨性病变。开放性活组织检查证实了 GCT 的诊断。决定用刚性领固定颈椎，并开始每月静脉注射唑来膦酸。随后 3 年的临床和影像学随访显示病变明显消退。
双膦酸盐药物在颈椎 GCT 中的应用显示出了潜在的治疗益处，这与其他溶骨性疾病的先前描述一致。这一发现可能促使进一步研究这些药物作为骨 GCT 辅助治疗的作用和真正价值。
