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Differences in open state of NBA-modified cardiac Na+ channels.

作者信息

Kohlhardt M, Fichtner H, Fröbe U

机构信息

Physiological Institute, University Freiburg, Federal Republic of Germany.

出版信息

Eur Biophys J. 1988;15(5):289-92. doi: 10.1007/BF00256479.

DOI:10.1007/BF00256479
PMID:2452729
Abstract

Patch clamp recordings from neonatal cardiac Na+ channels treated with N-bromoacetamide (NBA, 5-50 X 10- mol/l) showed modified Na+ channel activity. By chemical removal of inactivation, repetitive openings with an increased life time and burst-like activity occurred. NBA-modified Na+ channels differ in life time and may attain either a slightly (mean open time 3.1 +/- 0.2 ms) or a strongly (mean open time 15.2 +/- 1.4 ms) prolonged open state. This strongly suggests a heterogeneous population of NBA-modified Na+ channels in newborn rat cardiocytes.

摘要

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引用本文的文献

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本文引用的文献

1
Two types of voltage dependent na channels suggested by differential sensitivity of single channels to tetrodotoxin.单通道对河豚毒素的不同敏感性提示存在两种电压依赖性钠通道。
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Statistical analysis of single sodium channels. Effects of N-bromoacetamide.
单钠通道的统计分析。N-溴乙酰胺的作用。
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Sodium and calcium channels in bovine chromaffin cells.牛嗜铬细胞中的钠通道和钙通道。
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Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches.N-溴乙酰胺对膜片钳单钠通道电流的影响。
J Gen Physiol. 1982 Mar;79(3):333-51. doi: 10.1085/jgp.79.3.333.
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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.用于从细胞和无细胞膜片进行高分辨率电流记录的改进膜片钳技术。
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Functional differences between two classes of sodium channels in developing rat skeletal muscle.
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Modification of single cardiac Na+ channels by DPI 201-106.
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