Yu Ting-Ting, Han Zhi-Gang, Shan Li, Tao Jie, Zhang Tao, Yuan Shuai-Fei, Shen Hong-Li
Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, China E-mail :
Asian Pac J Cancer Prev. 2014;15(1):29-32. doi: 10.7314/apjcp.2014.15.1.29.
Lung cancer is one of the malignant diseases which most seriously threat humansurvival and development. This study aimed to assess osteopontin (OPN) expression in non-small cell lung cancer (NSCLC) and any relationship with clinicopathological features.
Immunohistochemistry was used to determine OPN expression and microvascular density (MVD) in 120 cases of NSCLC also undergoing clinical assessment.
Moderately positive expression of OPN was found in 34.6% (41/120) and strong expression in 47.5% (57/120) of the NSCLCs; OPN expression in carcinomas was higher than in pericarcinoma tissues (P<0.05). While no obvious association was observed with NSCLC patient age, gender, maximum diameter of the tumor and pathological type, OPN expression was more commonly detected in poorly differentiated carcinoma tissue and lymph node metastasis as well as at advanced clinical stage (P<0.05); OPN expression in cancer tissue was positively correlated with MVD (r = 0.839, P = 0.000).
OPN plays an important role in promoting tumor angiogenesis and progress of NSCLCs and has the possibility to become the new target for therapy.
肺癌是最严重威胁人类生存与发展的恶性疾病之一。本研究旨在评估骨桥蛋白（OPN）在非小细胞肺癌（NSCLC）中的表达及其与临床病理特征的关系。
采用免疫组织化学法检测120例接受临床评估的NSCLC患者中OPN的表达及微血管密度（MVD）。
NSCLC中34.6%（41/120）呈中度阳性表达，47.5%（57/120）呈强阳性表达；癌组织中OPN表达高于癌旁组织（P<0.05）。OPN表达与NSCLC患者的年龄、性别、肿瘤最大径及病理类型无明显相关性，但在低分化癌组织、有淋巴结转移及临床晚期患者中更常见（P<0.05）；癌组织中OPN表达与MVD呈正相关（r = 0.839，P = 0.000）。
OPN在促进NSCLC肿瘤血管生成和进展中起重要作用，有可能成为新的治疗靶点。
