Oxenkrug G, McIntyre I, McCauley R, Yuwiler A
Department of Psychiatry, Wayne State University Medical School, Detroit, Michigan.
J Pineal Res. 1988;5(1):99-109. doi: 10.1111/j.1600-079x.1988.tb00772.x.
Freshly cultured pineal glands respond to the monoamine oxidase A (MAO A) inhibitor clorgyline and to high concentrations of the MAO B inhibitor, deprenyl, with an increase in serotonin N-acetyltransferase activity and N-acetylated indoles and a fall in 5-hydroxylated serotonin degradation products. Glands cultured for 48 hours before challenge respond less. Response is absent in glands cultured for 72 hours and in glands from ganglionectomized animals cultured for 48 hours before challenge. These data are consistent with the hypothesis that these MAO inhibitors stimulate melatonin synthesis by protecting norepinephrine from degradation.
新鲜培养的松果体对单胺氧化酶A（MAO A）抑制剂氯吉兰以及高浓度的MAO B抑制剂司来吉兰有反应，表现为血清素N - 乙酰基转移酶活性增加、N - 乙酰化吲哚增加以及5 - 羟基血清素降解产物减少。在接受刺激前培养48小时的腺体反应较弱。在接受刺激前培养72小时的腺体以及来自节前切除动物且培养48小时的腺体则无反应。这些数据与以下假设一致，即这些MAO抑制剂通过保护去甲肾上腺素不被降解来刺激褪黑素的合成。
