Jensen David Hebbelstrup, Oliveri Roberto Stefan, Trojahn Kølle Stig-Frederik, Fischer-Nielsen Anne, Specht Lena, Bardow Allan, Buchwald Christian
Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital Rigshospitalet, and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Cell Therapy Facility, Blood Bank, Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Mar;117(3):335-342.e1. doi: 10.1016/j.oooo.2013.11.496. Epub 2013 Dec 8.
The most severe forms of xerostomia and salivary gland dysfunction, as well as a severely reduced quality of life, are seen in Sjögren syndrome (SS) and after radiotherapy for head and neck cancer. For both conditions, no effective regenerative therapies yet exist. Thus, the aim of this article was to assess, through systematic review, the potential benefit of mesenchymal stem cell (MSC) therapy in radiation-induced and SS-related salivary gland dysfunction and xerostomia. We searched PubMed/MEDLINE, Embase, Web of Science, the Cochrane Database of Systematic Reviews, the World Health Organization Clinical Trials Registry Platform, and Google Scholar. We identified 6 separate study comparisons eligible for inclusion. Owing to the limited number of studies, we conclude that more randomized, adequately powered clinical trials are needed to validate the potential beneficial effect of MSCs on salivary gland dysfunction and xerostomia. Nonetheless, the preliminary studies identified in the present review were encouraging for further research.
在干燥综合征（SS）以及头颈部癌症放疗后，会出现最严重形式的口干症和唾液腺功能障碍，同时生活质量也会严重下降。对于这两种情况，目前尚无有效的再生疗法。因此，本文的目的是通过系统评价，评估间充质干细胞（MSC）疗法对放疗引起的以及与SS相关的唾液腺功能障碍和口干症的潜在益处。我们检索了PubMed/MEDLINE、Embase、Web of Science、Cochrane系统评价数据库、世界卫生组织临床试验注册平台和谷歌学术。我们确定了6项符合纳入标准的独立研究比较。由于研究数量有限，我们得出结论，需要更多随机、有足够样本量的临床试验来验证MSC对唾液腺功能障碍和口干症的潜在有益作用。尽管如此，本综述中确定的初步研究结果为进一步研究提供了鼓舞。
