先天抵抗弓形虫：老鼠、猫和人类的进化故事。
Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.
机构信息
Immunopathology Laboratory, René Rachou Institute, Oswaldo Cruz Foundation-Minas Gerais, 30190-002, Belo Horizonte, MG, Brazil; Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605-02324, USA.
Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.
出版信息
Cell Host Microbe. 2014 Feb 12;15(2):132-8. doi: 10.1016/j.chom.2014.01.004.
Abstract
Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed.
摘要
最近的研究揭示了 Toll 样受体 (TLR) TLR11 和 TLR12 以及免疫相关 GTP 酶 (IRG) 蛋白的显著物种特异性，这些蛋白是在小鼠中检测和免疫控制刚地弓形虫所必需的，但在人类中并非如此。讨论了这些发现对刚地弓形虫宿主-病原体关系和人类疾病的生物学和进化意义。
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