高甘油三酯血症和低 HDL 是否是胰岛素抵抗发展的原因？
Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?
机构信息
University of Groningen, University Medical Center Groningen, Department of Molecular Genetics, Groningen, The Netherlands; Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
出版信息
Atherosclerosis. 2014 Mar;233(1):130-8. doi: 10.1016/j.atherosclerosis.2013.12.013. Epub 2014 Jan 7.
Insulin resistance often occurs with dyslipidemia as part of the metabolic syndrome and the current dominant paradigm is that insulin resistance leads to dyslipidemia. However, dyslipidemia may also cause insulin resistance; this was postulated 30 years ago, but has never been substantiated. Establishing whether dyslipidemia plays a causal role in the etiology of insulin resistance is important since it could reveal new avenues for combating type 2 diabetes. In this review we summarize recent evidence from epidemiological, genetic and intervention studies to re-address this old hypothesis.
胰岛素抵抗常伴有血脂异常，作为代谢综合征的一部分，目前占主导地位的观点认为胰岛素抵抗导致血脂异常。然而，血脂异常也可能导致胰岛素抵抗；这一观点在 30 年前就已经提出，但从未得到证实。确定血脂异常是否在胰岛素抵抗的发病机制中起因果作用非常重要，因为这可能为治疗 2 型糖尿病开辟新途径。在这篇综述中，我们总结了来自流行病学、遗传学和干预研究的最新证据，重新探讨这一旧假说。
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