早发冠心病患者血浆致动脉粥样硬化指数与主要不良心血管事件的关联

Association between the atherogenic index of plasma and major adverse cardiovascular events in patients with premature coronary artery disease.

作者信息

Ran Xiangzhen, Wu Zhenguo, Guo Dachuan, Zhang Shuai, Liu Li, Chen Sha, Song Chunfei, Zhang Cheng, Yang Jianmin

机构信息

State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research of MOE, NHC, CAMS and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.

出版信息

Eur J Med Res. 2025 Jun 23;30(1):511. doi: 10.1186/s40001-025-02796-w.

DOI:10.1186/s40001-025-02796-w

PMID:40551214

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12183880/

Abstract

BACKGROUND

The atherogenic index of plasma (AIP) as a novel lipid biomarker has been shown to be an important predictor of atherosclerosis and coronary artery disease. However, it remains unclear whether AIP has prognostic value for patients with premature coronary artery disease (PCAD). Therefore, the present investigation aims to explore the relationship between AIP and major adverse cardiovascular events (MACE) in the PCAD population.

METHODS

A total of 721 patients with PCAD diagnosed by coronary angiography were enrolled in this study. Their AIP was calculated as log [triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C)]. The primary outcome of this study was MACE, defined as a combination of cardiovascular (CV) death, coronary artery revascularization, non-fatal myocardial infarction (MI), and non-fatal stroke.

RESULTS

After a median follow-up time of 52 months, 138 patients developed MACE. The patients in the highest AIP tertile group have a higher incidence of MACE (26.6% vs 11.8% and 19.8%, p < 0.001). The Kaplan-Meier curves demonstrated that there were significant differences in the risk of MACE among different AIP groups (log-rank p < 0.001). In addition, the multivariable Cox regression model showed that the hazard ratio of MACE in the highest tertile group was 2.27 (95% CI 1.30-3.94), and 1.33 (95% CI 1.06-1.67) for per SD increase in AIP.

CONCLUSIONS

AIP is significantly associated with the risk of MACE in patients with PCAD and serves as a novel independent prognostic marker for this population.

摘要

背景

血浆致动脉粥样硬化指数（AIP）作为一种新型脂质生物标志物，已被证明是动脉粥样硬化和冠状动脉疾病的重要预测指标。然而，AIP对早发冠状动脉疾病（PCAD）患者是否具有预后价值仍不清楚。因此，本研究旨在探讨PCAD人群中AIP与主要不良心血管事件（MACE）之间的关系。

方法

本研究共纳入721例经冠状动脉造影诊断为PCAD的患者。他们的AIP计算为log[甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）]。本研究的主要结局是MACE，定义为心血管（CV）死亡、冠状动脉血运重建、非致死性心肌梗死（MI）和非致死性卒中的组合。

结果

中位随访时间52个月后，138例患者发生MACE。AIP最高三分位数组的患者发生MACE的发生率更高（26.6%对11.8%和19.8%，p<0.001）。Kaplan-Meier曲线显示，不同AIP组之间MACE风险存在显著差异（对数秩检验p<0.001）。此外，多变量Cox回归模型显示，最高三分位数组MACE的风险比为2.27（95%CI 1.30-3.94），AIP每增加1个标准差，风险比为1.33（95%CI 1.06-1.67）。