每月静脉注射大剂量甲泼尼龙治疗慢性炎症性脱髓鞘性多发性神经病五年：10年随访

Treatment of chronic inflammatory demyelinating polyneuropathy with high dose intravenous methylprednisolone monthly for five years: 10-Year follow up.

作者信息

Börü Ülkü Türk, Erdoğan Hülya, Alp Recep, Taşdemir Mustafa, Yıldırım Serhan, Bilgiç Adnan, Duman Arda, Arslan Alper

机构信息

Dr. Lütfi Kırdar Kartal Training and Research Hospital, Department of Neurology, Şemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890 İstanbul, Turkey.

Department of Neurology, Namık Kemal University, Faculty of Medicine, Değirmenaltı Yerleşkesi, 59030 Tekirdağ, Turkey.

出版信息

Clin Neurol Neurosurg. 2014 Mar;118:89-93. doi: 10.1016/j.clineuro.2014.01.001. Epub 2014 Jan 14.

DOI:10.1016/j.clineuro.2014.01.001

PMID:24529237

Abstract

OBJECTIVE

Although various modalities of treatment of chronic inflammatory demyelinating polyradiculopathy (CIDP) there are not any treatment protocol agreed.

MATERIALS AND METHODS

We retrospectively evaluated the 20 CIDP patients (14 male, 6 female). Five patients were excluded from the study because they could not continue their treatments due to various problems during the treatment. The remaining 15 patients treated with monthly high dose intravenous methyl prednisolone for five years (IVMP) and followed up for 10 years.

RESULTS

The mean age of the patients was 48.1±14.6 years. The mean duration of disease was 6.8±3.1 years. We were found statistically significant difference between the pre-treatment and sixth month modified Rankin scores (p<0.001). Similarly, significant improvement was observed at the end of first, fourth and fifth years of treatment. Statistically significant difference was found between baseline and tenth year modified Rankin scores of 12 patients who were treated with only IVMP during 10 years follow-up.

CONCLUSION

Long-term monthly IVMP pulse therapy seems to be very effective in the treatment of CIDP.

摘要

目的

尽管慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）有多种治疗方式，但尚无任何达成共识的治疗方案。

材料与方法

我们回顾性评估了20例CIDP患者（14例男性，6例女性）。5例患者因在治疗期间出现各种问题无法继续治疗而被排除在研究之外。其余15例患者接受每月一次高剂量静脉注射甲基强的松龙治疗五年（IVMP），并随访10年。

结果

患者的平均年龄为48.1±14.6岁。疾病的平均病程为6.8±3.1年。我们发现治疗前与治疗后第六个月的改良Rankin评分之间存在统计学显著差异（p<0.001）。同样，在治疗的第一、第四和第五年末观察到显著改善。在10年随访期间仅接受IVMP治疗的12例患者的基线与第十年改良Rankin评分之间存在统计学显著差异。