Kegler K, Mundle K, Walliser U, Wohlsein P
Department of Pathology, University of Veterinary Medicine, Bünteweg 17, D-30559 Hannover, Germany.
Pferdeklinik in Kirchheim, Dr. U. Walliser, Nürtinger Straße 200, D-73230 Kirchheim/Teck, Germany.
J Comp Pathol. 2014 May;150(4):382-7. doi: 10.1016/j.jcpa.2013.12.004. Epub 2013 Dec 17.
Schwannomas arising in the parotid gland are rare in man and are not documented in domestic animals. This report describes the clinical, morphological and immunohistochemical findings of a benign schwannoma in the parotid gland of a 12-year-old warmblood gelding. A slow-growing mass was surgically excised from the parotid gland and did not recur within the following 6 months. The tumour was well circumscribed and was composed of densely packed spindle cells partly arranged in an Antoni A pattern and intermixed with hypocellular areas resembling the Antoni B pattern. Tumour cells expressed vimentin, S100 protein, glial fibrillary acidic protein and variably neuron-specific enolase. Less than 5% of the neoplastic cells were immunolabelled with the proliferation marker Ki67. Although malignant melanomas frequently involve the parotid gland in horses, schwannomas should be included in the differential diagnosis of parotid masses.
腮腺神经鞘瘤在人类中罕见，在家畜中尚无记载。本报告描述了一匹12岁温血阉马腮腺良性神经鞘瘤的临床、形态学和免疫组化结果。从腮腺手术切除一个生长缓慢的肿块，在随后6个月内未复发。肿瘤边界清晰，由紧密排列的梭形细胞组成，部分呈Antoni A型排列，并与类似Antoni B型的细胞稀少区域混合。肿瘤细胞表达波形蛋白、S100蛋白、胶质纤维酸性蛋白和可变的神经元特异性烯醇化酶。不到5%的肿瘤细胞被增殖标记物Ki67免疫标记。尽管恶性黑色素瘤在马匹中常累及腮腺，但神经鞘瘤应纳入腮腺肿块的鉴别诊断。
