Palomaki G E, Hill L E, Knight G J, Haddow J E, Carpenter M
Foundation for Blood Research, Scarborough, Maine.
Obstet Gynecol. 1988 Jun;71(6 Pt 1):906-9.
This population-based study analyzes maternal serum alpha-fetoprotein (MSAFP) distributions for 20 cases of gastroschisis and 13 cases of omphalocele occurring in singleton pregnancies from among 72,782 second-trimester pregnancies in Maine and Rhode Island screened consecutively between January 1, 1979 and February 28, 1987. Median values (and ranges) for the two lesions were 4.1 multiples of the median (0.5-29.8) for omphalocele and 7.0 multiples of the median (3.6-13.5) for gastroschisis. The MSAFP distributions for the two conditions were both log-Gaussian, and the log standard deviation was smaller for gastroschisis than for omphalocele. The MSAFP screening sensitivity was greater for gastroschisis than for omphalocele at any given cutoff, and the overall sensitivity of this screening process for detecting open ventral wall defects will differ, therefore, depending upon the relative proportion of gastroschisis and omphalocele cases that occur in the screened population.
这项基于人群的研究分析了1979年1月1日至1987年2月28日期间在缅因州和罗德岛连续筛查的72782例中期妊娠单胎妊娠中，20例腹裂和13例脐膨出的孕妇血清甲胎蛋白（MSAFP）分布情况。两种病变的中位数（及范围）分别为：脐膨出为中位数的4.1倍（0.5 - 29.8），腹裂为中位数的7.0倍（3.6 - 13.5）。两种情况的MSAFP分布均呈对数高斯分布，腹裂的对数标准差小于脐膨出。在任何给定的临界值下，腹裂的MSAFP筛查敏感性均高于脐膨出，因此，这种筛查过程检测开放性腹壁缺陷的总体敏感性将有所不同，这取决于筛查人群中腹裂和脐膨出病例的相对比例。
