杀还是不杀，这是个问题：细胞毒性抗疟药物耐药性。
To kill or not to kill, that is the question: cytocidal antimalarial drug resistance.
机构信息
Department of Chemistry, Georgetown University, 37th and O Streets NW, Washington DC 20057, USA; Department of Biochemistry and Cellular and Molecular Biology, Georgetown University, 37th and O Streets NW, Washington DC 20057, USA.
出版信息
Trends Parasitol. 2014 Mar;30(3):130-5. doi: 10.1016/j.pt.2014.01.004. Epub 2014 Feb 13.
Abstract
Elucidating mechanisms of antimalarial drug resistance accelerates development of improved diagnostics and the design of new, effective malaria therapy. Recently, several studies have emphasized that chloroquine (CQ) resistance (CQR) can be quantified in two very distinct ways, depending on whether sensitivity to the growth inhibitory effects or parasite-kill effects of the drug are being measured. It is now clear that these cytostatic and cytocidal CQR phenotypes are not equivalent, and recent genetic, cell biological, and biophysical evidence suggests how the molecular mechanisms may overlap. These conclusions have important implications for elucidating other drug resistance phenomena and emphasize new concepts that are essential for the development of new drug therapy.
摘要
阐明抗疟药物耐药机制可以加速改进诊断方法的开发和新的有效疟疾治疗方法的设计。最近，有几项研究强调，根据所测量的药物对生长抑制作用或杀伤寄生虫效果的敏感性，可以用两种截然不同的方式来量化氯喹（CQ）耐药性（CQR）。现在很清楚，这两种细胞抑制和细胞杀伤的 CQR 表型并不等同，最近的遗传、细胞生物学和生物物理证据表明，分子机制可能如何重叠。这些结论对抗疟药耐药现象的阐明具有重要意义，并强调了对新药治疗开发至关重要的新概念。
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