班氏试验在半乳糖血症筛查中的效用。
Usefulness of Benedict's test for the screening of galactosemia.
作者信息
Morell-Garcia Daniel, Bauça Josep Miquel, Barceló Antonia, Perez-Esteban Gerardo, Vila Magdalena
机构信息
Servei d'Anàlisis Clíniques, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
Secció d'Endocrinologia, Servei d'Anàlisis Clíniques, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
出版信息
Clin Biochem. 2014 Jun;47(9):857-9. doi: 10.1016/j.clinbiochem.2014.02.005. Epub 2014 Feb 12.
BACKGROUND
Benedict's test for the screening of galactosemia presents a high false-positive rate, which puts into question its usefulness.
METHODS
We evaluated the results of Benedict's test as screening strategy for galactosemia, and the patients' definite diagnosis in our hospital in the last 25 years. We also assessed the most prevalent clinical conditions among the false-positive cases.
RESULTS
Apart from glycosuria, many non-galactosemic newborns with heart alterations, prematurity, icterus and sepsis usually lead to false-positive results using Benedict's. No false-negative case for Benedict's test was reported in our hospital.
CONCLUSIONS
A better approach in terms of cost-effectiveness, sensitivity and specificity is needed for an effective screening of galactosemia.
背景
用于半乳糖血症筛查的本尼迪克特试验呈现出较高的假阳性率，这使其效用受到质疑。
方法
我们评估了本尼迪克特试验作为半乳糖血症筛查策略的结果，以及过去25年我院患者的明确诊断情况。我们还评估了假阳性病例中最常见的临床状况。
结果
除了糖尿外，许多患有心脏病变、早产、黄疸和败血症的非半乳糖血症新生儿使用本尼迪克特试验通常会导致假阳性结果。我院未报告本尼迪克特试验的假阴性病例。
结论
为了有效筛查半乳糖血症，需要在成本效益、敏感性和特异性方面采用更好的方法。
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