Clinical Research Institute and Goldberg Center for Community Pediatric Health, Children's National Health System, 111 Michigan Ave, NW Washington, DC, WA 20010, United States.
Western Sydney Sexual Health Centre, The University of Sydney, Level 4 Jeffery House, 162 Marsden Street, Parramatta 2150, NSW, Australia.
Vaccine. 2014 Apr 7;32(17):1901-20. doi: 10.1016/j.vaccine.2014.01.091. Epub 2014 Feb 14.
The Human papillomavirus (HPV) vaccine has been available for protection against HPV-associated cervical cancer and genital warts since 2006. Nonetheless, uptake has varied among countries and populations within countries. Studies have found that individuals' knowledge and attitudes toward the vaccine are associated with immunization uptake. The purpose of the current review is to summarize and evaluate the evidence for educational interventions to increase HPV vaccination acceptance.
We searched the databases of PubMed and Web of Science for English-language articles describing educational interventions designed to improve HPV vaccination uptake, intention or attitude.
We identified 33 studies of HPV vaccination educational interventions: 7 tested the effectiveness of interventions with parents, 8 with adolescents or young adults, and 18 compared the effectiveness of different message frames in an educational intervention among adolescents, young adults or their parents. Most studies involved populations with higher educational attainment and most interventions required participants to be literate. The minority of studies used the outcome of HPV vaccine uptake. Well-designed studies adequately powered to detect change in vaccine uptake were rare and generally did not demonstrate effectiveness of the tested intervention.
There is not strong evidence to recommend any specific educational intervention for wide-spread implementation. Future studies are required to determine the effectiveness of culturally-competent interventions reaching diverse populations.
自 2006 年以来，人乳头瘤病毒（HPV）疫苗已可用于预防 HPV 相关的宫颈癌和生殖器疣。然而，各国和各国国内不同人群的疫苗接种率存在差异。研究发现，个人对疫苗的知识和态度与免疫接种率有关。本综述的目的是总结和评估旨在提高 HPV 疫苗接种率的教育干预措施的证据。
我们在 PubMed 和 Web of Science 数据库中搜索了描述旨在提高 HPV 疫苗接种率、意愿或态度的教育干预措施的英文文章。
我们确定了 33 项 HPV 疫苗接种教育干预措施的研究：7 项研究测试了针对父母的干预措施的有效性，8 项研究针对青少年或年轻人，18 项研究比较了青少年、年轻人或其父母的教育干预措施中不同信息框架的有效性。大多数研究涉及受教育程度较高的人群，大多数干预措施要求参与者具有读写能力。少数研究使用 HPV 疫苗接种的结果。设计良好、有足够能力检测疫苗接种变化的研究很少，并且通常不能证明所测试的干预措施的有效性。
没有强有力的证据推荐任何特定的教育干预措施广泛实施。需要进一步研究来确定针对不同人群的具有文化适应性的干预措施的有效性。
