Pawłowska D, Koćmierska-Grodzka D, Moniuszko-Jakoniuk J
Department of Toxicology, Institute of Pharmacology and Toxicology, Medical Academy, Białystok, Poland.
Pol J Pharmacol Pharm. 1987 Jul-Aug;39(4):361-70.
The experiment was carried out on Wistar rats receiving orally either oil or oily solution of methylbromophenvinfos (Polfos) either in a single dose of 0.5 LD50, or doses of 0.1 LD50 once daily for a period of 2, 4 or 6 weeks. The activities of cholinesterase (ChE), beta-glucuronidase (beta-glu), lipase and amylase were assayed in the blood serum, the activity of acetylcholinesterase (AChE)-in brain homogenates, and the activities of lipase and amylase-in homogenates of the pancreas. Cholinesterases were inhibited in the course of both acute and chronic poisoning with Polfos. During the acute poisoning a sharp increase in the activity of beta-glu in the blood serum, 1 and 2 h after the pesticide administration, was observed. Polfos inhibited lipase and amylase both after acute and chronic treatment.
实验选用Wistar大鼠，分别口服油剂或甲基溴苯磷（保棉磷）的油溶液，单次剂量为0.5 LD50，或每日剂量为0.1 LD50，持续2、4或6周。测定血清中胆碱酯酶（ChE）、β-葡萄糖醛酸酶（β-glu）、脂肪酶和淀粉酶的活性，脑匀浆中乙酰胆碱酯酶（AChE）的活性，以及胰腺匀浆中脂肪酶和淀粉酶的活性。保棉磷急性和慢性中毒过程中胆碱酯酶均受到抑制。急性中毒时，给药后1小时和2小时血清中β-glu活性急剧升高。保棉磷急性和慢性处理后均抑制脂肪酶和淀粉酶。
