血浆可溶性α-klotho 与 2 型糖尿病患者前内皮素-1 的关系。
Association of plasma soluble α-klotho with pro-endothelin-1 in patients with type 2 diabetes.
机构信息
Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore.
Institut für Experimentelle Endokrinologie, Charité Universitätsmedizin Berlin, Germany.
出版信息
Atherosclerosis. 2014 Apr;233(2):415-418. doi: 10.1016/j.atherosclerosis.2014.01.024. Epub 2014 Jan 22.
OBJECTIVES
To study the relationship between plasma soluble klotho (sKlotho) and pro-endothelin-1 (proET-1) in patients with type 2 diabetes (T2DM).
SUBJECTS AND METHODS
In this cross-sectional study, we recruited 175 T2DM subjects and 56 non-diabetic controls. Plasma sKlotho, proET-1 and extracellular superoxide dismutase (SOD) were measured by ELISA and ILMA, respectively.
RESULTS
Plasma sKlotho level in patients with T2DM was lower compared to that in non-diabetic controls (416.8±148.1 vs. 494.6±134.3 pg/ml, p=0.001) and showed significant interaction with diabetes status in its association with proET-1. Plasma sKlotho was inversely correlated with proET-1 in T2DM (Rho=-0.410, p<0.0001) but not in non-diabetic controls (Rho=0.091, p=0.505). Multivariable linear regression models revealed that sKlotho was independently associated with proET-1 after adjustment for renal filtration function, albuminuria, diabetes duration, HbA1c, systolic and diastolic blood pressure.
CONCLUSIONS
Plasma sKlotho was associated with proET-1 independent of renal function in patients with T2DM.
目的
研究 2 型糖尿病（T2DM）患者血浆可溶性 klotho（sKlotho）与前内皮素-1（proET-1）之间的关系。
受试者和方法
在这项横断面研究中，我们招募了 175 名 T2DM 患者和 56 名非糖尿病对照者。通过 ELISA 和 ILMA 分别测量血浆 sKlotho、proET-1 和细胞外超氧化物歧化酶（SOD）。
结果
与非糖尿病对照组相比，T2DM 患者的血浆 sKlotho 水平较低（416.8±148.1 vs. 494.6±134.3 pg/ml，p=0.001），并且与 proET-1 的相关性存在显著的糖尿病状态交互作用。T2DM 患者的血浆 sKlotho 与 proET-1 呈负相关（Rho=-0.410，p<0.0001），而非糖尿病对照组则无相关性（Rho=0.091，p=0.505）。多变量线性回归模型显示，在调整肾功能、白蛋白尿、糖尿病病程、HbA1c、收缩压和舒张压后，sKlotho 与 proET-1 独立相关。
结论
在 T2DM 患者中，血浆 sKlotho 与 proET-1 相关，与肾功能无关。
Zotero 插件