Dalger J, Dussarat G V, Dumoulin M
Service de Cardiologie, Hôpital d'Instruction des Armées Sainte-Anne, Toulon-Naval.
Ann Cardiol Angeiol (Paris). 1988 Apr;37(4):191-3.
The authors report a case of thrombopenia induced by pentosane polysulfate (PSP), complicated by a myocardial infarction. Biological tests showed a platelet pro-aggregating effect of PSP and an IgG immunoglobulin fixed to the platelets. A review of the literature shows that PSP-induced thrombopenias must be known as well as those induced by heparins and that they have similar complications. The thrombopenia may persist with an inappropriate substitution with heparin and the clinical picture may be aggravated. It is desirable to carry out systematic screening for a cross-allergy and prevent it by using anti-vitamin K.
作者报告了一例戊聚糖多硫酸盐（PSP）诱发的血小板减少症，并伴有心肌梗死。生物学检测显示PSP具有血小板促聚集作用，且有IgG免疫球蛋白附着于血小板。文献综述表明，必须了解PSP诱发的血小板减少症以及肝素诱发的血小板减少症，并且它们有相似的并发症。用肝素进行不恰当替代时，血小板减少症可能会持续存在，临床症状可能会加重。进行交叉过敏的系统筛查并使用维生素K拮抗剂预防是可取的。
